{"@context":"http://schema.org","@type":"Dataset","@id":"https://doi.org/10.60933/PRDR/RWJUCX","identifier":"https://doi.org/10.60933/PRDR/RWJUCX","name":"Lysine Deprivation Suppresses Adipogenesis in 3T3-L1 Cells: A Transcriptome Analysis","creator":[{"@type":"Person","givenName":"Leo Man Yuen","familyName":"Lee","affiliation":{"@type":"Organization","name":"Hong Kong Polytechnic University"},"sameAs":"https://orcid.org/0000-0002-2089-9311","@id":"https://orcid.org/0000-0002-2089-9311","identifier":"https://orcid.org/0000-0002-2089-9311","name":"Lee, Leo Man Yuen"},{"@type":"Person","givenName":"Thomas Yun-chung","familyName":"Leung","affiliation":{"@type":"Organization","name":"Hong Kong Polytechnic University"},"sameAs":"https://orcid.org/0000-0003-3590-7027","@id":"https://orcid.org/0000-0003-3590-7027","identifier":"https://orcid.org/0000-0003-3590-7027","name":"Leung, Thomas Yun-chung"}],"author":[{"@type":"Person","givenName":"Leo Man Yuen","familyName":"Lee","affiliation":{"@type":"Organization","name":"Hong Kong Polytechnic University"},"sameAs":"https://orcid.org/0000-0002-2089-9311","@id":"https://orcid.org/0000-0002-2089-9311","identifier":"https://orcid.org/0000-0002-2089-9311","name":"Lee, Leo Man Yuen"},{"@type":"Person","givenName":"Thomas Yun-chung","familyName":"Leung","affiliation":{"@type":"Organization","name":"Hong Kong Polytechnic University"},"sameAs":"https://orcid.org/0000-0003-3590-7027","@id":"https://orcid.org/0000-0003-3590-7027","identifier":"https://orcid.org/0000-0003-3590-7027","name":"Leung, Thomas Yun-chung"}],"datePublished":"2024-06-06","dateModified":"2024-06-06","version":"1","description":"Organism: Mus musculus Summary: It has been reported that low concentration of lysine suppressed lipid accumulation and transcription of several adipogenic genes in 3T3-L1 preadipocytes, however, the detailed lysine deprivation-specific cellular transcriptomic changes and the altered pathways have not yet been fully decrypted. Overall design: Using 3T3-L1 cells, we performed RNA sequencing on undifferentiated cells, differentiated cells, and differentiated cells under a lysine-free culture medium","keywords":["Medicine, Health and Life Sciences"],"citation":[{"@type":"CreativeWork","name":"Lee, L. M. Y., Lin, Z. Q., Zheng, L. X., Tu, Y. F., So, Y. H., Zheng, X. H., ... & Leung, Y. C. (2023). Lysine Deprivation Suppresses Adipogenesis in 3T3-L1 Cells: A Transcriptome Analysis. International Journal of Molecular Sciences, 24(11), 9402","@id":"https://doi.org/10.3390/ijms24119402","identifier":"https://doi.org/10.3390/ijms24119402","url":"https://doi.org/10.3390/ijms24119402"},{"@type":"CreativeWork","name":"Link in PolyU Institutional Research Archive (PIRA)","@id":"http://hdl.handle.net/10397/99463","identifier":"http://hdl.handle.net/10397/99463","url":"http://hdl.handle.net/10397/99463"}],"license":"http://creativecommons.org/licenses/by-nc/4.0","includedInDataCatalog":{"@type":"DataCatalog","name":"PolyU Research Data Repository","url":"https://researchdata.lib.polyu.edu.hk"},"publisher":{"@type":"Organization","name":"PolyU Research Data Repository"},"provider":{"@type":"Organization","name":"PolyU Research Data Repository"},"distribution":[{"@type":"DataDownload","name":"SRR23252438.sra","encodingFormat":"application/octet-stream","contentSize":2160748798,"description":"Treatment: Adipogenic differentiation+lysine free medium","@id":"https://doi.org/10.60933/PRDR/RWJUCX/DQ03HI","identifier":"https://doi.org/10.60933/PRDR/RWJUCX/DQ03HI","contentUrl":"https://researchdata.lib.polyu.edu.hk/api/access/datafile/425"},{"@type":"DataDownload","name":"SRR23252439.sra","encodingFormat":"application/octet-stream","contentSize":2162965158,"description":"Treatment: Adipogenic differentiation+lysine free medium","@id":"https://doi.org/10.60933/PRDR/RWJUCX/QZF5RS","identifier":"https://doi.org/10.60933/PRDR/RWJUCX/QZF5RS","contentUrl":"https://researchdata.lib.polyu.edu.hk/api/access/datafile/426"},{"@type":"DataDownload","name":"SRR23252440.sra","encodingFormat":"application/octet-stream","contentSize":1998289600,"description":"Treatment: Adipogenic differentiation+lysine free medium","@id":"https://doi.org/10.60933/PRDR/RWJUCX/EILBMM","identifier":"https://doi.org/10.60933/PRDR/RWJUCX/EILBMM","contentUrl":"https://researchdata.lib.polyu.edu.hk/api/access/datafile/428"},{"@type":"DataDownload","name":"SRR23252441.sra","encodingFormat":"application/octet-stream","contentSize":2001950955,"description":"Treatment: Adipogenic differentiation","@id":"https://doi.org/10.60933/PRDR/RWJUCX/AVYJD6","identifier":"https://doi.org/10.60933/PRDR/RWJUCX/AVYJD6","contentUrl":"https://researchdata.lib.polyu.edu.hk/api/access/datafile/429"},{"@type":"DataDownload","name":"SRR23252442.sra","encodingFormat":"application/octet-stream","contentSize":2314735802,"description":"Treatment: Adipogenic differentiation","@id":"https://doi.org/10.60933/PRDR/RWJUCX/AZKJAM","identifier":"https://doi.org/10.60933/PRDR/RWJUCX/AZKJAM","contentUrl":"https://researchdata.lib.polyu.edu.hk/api/access/datafile/430"},{"@type":"DataDownload","name":"SRR23252443.sra","encodingFormat":"application/octet-stream","contentSize":1924932821,"description":"Treatment: Adipogenic differentiation","@id":"https://doi.org/10.60933/PRDR/RWJUCX/YPJ1G3","identifier":"https://doi.org/10.60933/PRDR/RWJUCX/YPJ1G3","contentUrl":"https://researchdata.lib.polyu.edu.hk/api/access/datafile/431"},{"@type":"DataDownload","name":"SRR23252444.sra","encodingFormat":"application/octet-stream","contentSize":1907308965,"description":"Treatment: Undifferentiation control","@id":"https://doi.org/10.60933/PRDR/RWJUCX/SUTQG9","identifier":"https://doi.org/10.60933/PRDR/RWJUCX/SUTQG9","contentUrl":"https://researchdata.lib.polyu.edu.hk/api/access/datafile/427"},{"@type":"DataDownload","name":"SRR23252445.sra","encodingFormat":"application/octet-stream","contentSize":2623163255,"description":"Treatment: Undifferentiation control","@id":"https://doi.org/10.60933/PRDR/RWJUCX/PT8PKB","identifier":"https://doi.org/10.60933/PRDR/RWJUCX/PT8PKB","contentUrl":"https://researchdata.lib.polyu.edu.hk/api/access/datafile/432"},{"@type":"DataDownload","name":"SRR23252446.sra","encodingFormat":"application/octet-stream","contentSize":2485533710,"description":"Treatment: Undifferentiation control","@id":"https://doi.org/10.60933/PRDR/RWJUCX/YK1WYF","identifier":"https://doi.org/10.60933/PRDR/RWJUCX/YK1WYF","contentUrl":"https://researchdata.lib.polyu.edu.hk/api/access/datafile/433"}]}